In 1797, a Gloucestershire surgeon called Edward Jenner protected a small boy from smallpox by inoculating him with cowpox. In 1977, nearly two centuries after that first ‘vaccination’, a hospital cook called Ali Maow Maalin recovered from the last natural smallpox infection. Thanks to Jenner’s insight, we no longer live with smallpox.
By then, it was clear that Jenner’s insight was merely the beginning.
During the 1870s, Louis Pasteur led a revolution in medical science by showing that microbes cause disease. He didn’t stop there; he went on to modify microbes to protect against disease. He had turned the phenomenon discovered by Jenner into a set of principles and those principles have underpinned vaccine development for the last century and a half.
We now have an array of vaccines produced by techniques that Jenner and Pasteur could never have dreamed of and as microbes are constantly evolving, so must vaccinology. This is the story of vaccinology’s evolution from a Gloucestershire barnyard to the cutting-edge biotechnology that brings COVID-19 vaccines to the high street pharmacy.
Bio
David Miles is an infectious disease immunologist who has worked mostly on diseases of childhood in Africa and the vaccinations that protect against them. He now lives in London and tutors on the London School of Hygiene and Tropical Medicine’s online MSc course. His first popular science book, How Vaccines Work, was published in March 2023.
Website: https://www.variolator.com/
Twitter: @Variolator
Bluesky: @variolator.bsky.social
Standard Stuff
Talks are usually on the 4th Wednesday of every month, at 7:00 for 7:30, at The Winchester Club in Winchester. Please take a look at the FAQs for more info.
Admission is £5 which also gives you an entry in the book raffle. We take cash and major cards (cards preferred).
The event is in two parts – the talk and then a Q&A after the interval. We encourage you to support the venue by indulging in the available drinks before and during the event.
You are also welcome to join us for a drink in the bar after the event.
Science of the people, by the people, for the people
Ghostly encounters, alien abduction, reincarnation, talking to the dead, UFO sightings, inexplicable coincidences, out-of-body and near-death experiences… Are these legitimate phenomena? If not, then how should we go about understanding them?
You moan about them in your kitchen, you are filled with horror and rage at their persistence in trying to feast off you, and you turn away in disgust when spotting them feeding on faeces.
Those who watched the coronation of King Charles III in May 2023 would be forgiven for thinking that England is the very opposite of a secular country. But appearances can be deceptive. This talk will compare the British and French traditions of secularism and suggest that, like France, England is on its way to becoming a secular society, but without having adopted the French lay principle (laïcité).
Fluke: Chance, Chaos, and Why Everything We Do Matters
This lecture will show how Cockney English owes its origins to the Kings and Queens of the Kingdom of Essex. The story goes back sixteen hundred years, and it involves accents, class, snobbery, and rhyming slang.
Whether or not to smack children still remains a highly controversial topic in some communities. Even though in many countries smacking your child is now illegal, some people still consider that it is the parents’ right to do so.
Myths & Mindsets in a Decade of Electric Transport